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The Corn Lab
The Corn Lab develops and uses next-generation genome editing and regulation technologies. We work on both fundamental biological discovery and potential therapies for human genetic diseases. Our focus is the mechanisms by which cells repair their DNA, maintain and differentiate hematopoietic stem cells, and dispose of entire organelles. Through technology development, mechanistic cellular biochemistry, and translational projects, we are working to unravel complex cellular phenotypes to further biological understanding and improve human health.
Our work is supported by the Swiss National Science Foundation, the European Research Council, the NCCR RNA & Disease, the Fanconi Anemia Research Fund, the Bill and Melinda Gates Foundation, the NOMIS Foundation, and the Lotte und Adolf Holtz Foundation.
News
June 30, 2020
Pushing Cas9 off the genome, published in Molecular Cell
Cas9 is a great DNA cutting enzyme, but it’s also a little weird. Unlike other nucleases (such as restriction enzymes), S, pyogenes Cas9 sticks on ...
May 7, 2020
Increasing HDR by timed inhibition of CDC7, published in Nature Communications
When doing genome editing, fixing sequences by HDR is better than breaking them by making indels. If you really want to break something, you could even use HDR...
March 12, 2020
News Archive
Welcome to Lena
Welcome to Lena Kobel, who joins the lab as a Cell Line Engineer. Lena has a long history in genome engineering, with previous experience in Martin Jinek’s lab...
Blog - Making the Cut
March 12, 2020
0 Comments
Welcome to Lena
Welcome to Lena Kobel, who joins the lab as a Cell Line Engineer. Lena has a long history in genome engineering, with previous experience in Martin Jinek’s...
October 16, 2018
2 Comments
Bootstrapping a lab
Today I’m going to talk about setting up a lab from a 10,000 foot view. I got thinking about this because my social media feed was recently filled with people announcing...
June 12, 2017
1 Comment
Shapers and Mechanists
There’s a series of cyberpunk short stories and a book written in the 1980s by Bruce Sterling called The Schismatrix. It centers around two major offshoots...
June 1, 2017
1 Comment
Blog Archive
Backpacking season
It’s important to spend time outside the lab. And before you ask, that’s not why the blog has been dormant. I was teaching this last semester (a general biochemistry...
