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The Corn Lab
The Corn Lab develops and uses next-generation genome editing and regulation technologies. We work on both fundamental biological discovery and potential therapies for human genetic diseases. Our focus is the mechanisms by which cells repair their DNA, maintain and differentiate hematopoietic stem cells, and dispose of entire organelles. Through technology development, mechanistic cellular biochemistry, and translational projects, we are working to unravel complex cellular phenotypes to further biological understanding and improve human health.
Our work is supported by the Swiss National Science Foundation, the European Research Council, the NCCR RNA & Disease, the Fanconi Anemia Research Fund, the Bill and Melinda Gates Foundation, the NOMIS Foundation, and the Lotte und Adolf Holtz Foundation.
News
March 12, 2020
Welcome to Lena
Welcome to Lena Kobel, who joins the lab as a Cell Line Engineer. Lena has a long history in genome engineering, with previous experience in Martin Jinek’s lab...
March 12, 2020
ER-autophagy screen published in Cell
Did you know that cells eat their own organelles? This is best known when damaged mitochondria are degraded by autophagy (aka mitophagy). Failure to perform...
January 24, 2020
News Archive
Choosing the right path in genome editing – review published in Nature Cell Biology
Genome editing is all about DNA repair. So if you want to get your cells to do more of what you want (*cough* HDR *cough), you’d better know how they make ...
Blog - Making the Cut
March 12, 2020
0 Comments
Welcome to Lena
Welcome to Lena Kobel, who joins the lab as a Cell Line Engineer. Lena has a long history in genome engineering, with previous experience in Martin Jinek’s...
October 16, 2018
2 Comments
Bootstrapping a lab
Today I’m going to talk about setting up a lab from a 10,000 foot view. I got thinking about this because my social media feed was recently filled with people announcing...
June 12, 2017
1 Comment
Shapers and Mechanists
There’s a series of cyberpunk short stories and a book written in the 1980s by Bruce Sterling called The Schismatrix. It centers around two major offshoots...
June 1, 2017
1 Comment
Blog Archive
Backpacking season
It’s important to spend time outside the lab. And before you ask, that’s not why the blog has been dormant. I was teaching this last semester (a general biochemistry...
