People

Principal Investigator

Jacob Corn

Principal Investigator
+41 044 633 29 80

Jacob Corn is the Professor of Genome Biology... Read Bio

Jacob Corn is the Professor of Genome Biology at ETH Zürich. His research aims to bring about the end of genetic disease through the development and application of next-generation genome editing technologies. Jacob is committed to the improvement of human health through the fundamental understanding of disease mechanisms. Over the last fifteen years he has bridged academia and industry, working in therapeutic areas that include infectious disease, neurobiology, and oncology. His graduate studies at the University of California, Berkeley redefined our understanding of DNA replication and his postdoctoral work at the University of Washington computationally designed protein inhibitors from scratch. Jacob was a group leader at Genentech where he discovered biological mechanisms for challenging therapeutic targets. Prior to joining ETHZ, Jacob was the founding Scientific Director of the Innovative Genomics Institute and faculty at UC Berkeley. In his spare time, Jacob enjoys long backpacking trips and rock climbing

You can find Jacob on Twitter and LinkedIn.

Close

Staff

Luca Bechter

Research Technician
+41 44 633 36 15

Luca received his Master’s degree in Biolog... Read Bio

Luca received his Master’s degree in Biological Chemistry from the ETH Zürich in 2024. In his Master thesis he was working with Dr. Zacharias Kontarakis on establishing a pipeline for in-depth investigation of transcriptional adaptation in mammalian cells. Luca joined the Corn Lab as a Research Assistant in July 2024; his research interests are focused on the application of the gene editing tool CRISPR to further the understanding of gene expression and the possible influence on the medical field.

Close

Kinga Csorba

Lab Manager
+41 44 633 40 04

Kinga received her Phd in Biology/Autoimmune ... Read Bio

Kinga received her Phd in Biology/Autoimmune diseases from the University of Freiburg (Germany) in 2012, working with Dr. Cassian Sitaru and Stefan Martin PhD on autoimmune skin diseases, focusing on autoantibody-mediated pathomechanisms. During her postdoc in Basel (Switzerland), she continued her research in complement-involved autoimmune pathomechanisms in SLE. Kinga joined the Corn lab as a laboratory manager and technical assistant in May 2019.

Close

Jan Elias

Research Technician
+41 44 633 40 04

Jan received his Master´s degree in Immunolo... Read Bio

Jan received his Master´s degree in Immunology from Charles University in 2022, working with Dr. Petr Kašpárek on the role of TNFR1 signalling in the Netherton syndrome. Jan joined the Corn Lab as a Research Assistant in September 2022. His research interests include regulation of gene expression and synthetic biology, with a special focus on utilizing the CRISPRa/i technologies in therapeutic applications.

Close

ANA GVOZDENOVIC

Program Manager
+41 44 633 32 65

Ana received her PhD in Cancer Biology at the... Read Bio

Ana received her PhD in Cancer Biology at the University of Zurich, Switzerland. She carried out her pre-and postdoctoral research studies at the Balgrist University Hospital in Zurich focusing on understanding the molecular mechanisms of bone cancer progression and metastasis, identifying the key regulatory components as well as finding novel innovative therapeutic approaches. Later on, Ana initiated a new research field in the lab and was directly leading PhD students. The group was investigating the functional relevance of tumor-derived extracellular vesicles and microRNAs in metastatic sarcoma and their potential use as diagnostic and prognostic factors.

Prior to joining the Corn lab, Ana was working as a Clinical Scientist at ARTIDIS AG, a clinical stage health-tech start-up founded in Basel, Switzerland, that has developed the first nanomechanical biomarker for cancer diagnosis and treatment optimization.

Ana joined the Corn lab as a Program Manager in September 2022.

Close

Lena Kobel

Cell Line Engineer
+41 44 633 40 04

Lena Kobel received her Master’s degree in ... Read Bio

Lena Kobel received her Master’s degree in Cell Biology from the ETH Zürich in 2017. In her Master thesis she focused on generating stable mammalian cell lines using CRISPR-Cas9 in the lab of Prof. Martin Jinek at the University of Zürich, where she then worked for another 1.5 years as a technician. After that, she worked as an intern at Caribou Biosciences, Inc., in Berkeley for 6 months on a project focused on the development of CAR-T cell therapies. Lena joined the Corn lab as a Cell Line Engineer in March 2020.

Close

Zacharias Kontarakis

Head of the Genome Engineering and Measurement Lab

Zac received his PhD in Molecular Biology and... Read Bio

Zac received his PhD in Molecular Biology and Biomedicine from the Institute of Molecular Biology and Biotechnology in Crete in 2011, working with Dr. Michalis Averof on establishing genetic tools for functional developmental studies in emerging model organisms, focusing on gene trapping and site directed recombination.  He then moved to Prof. Didier Stainier Lab, initially in UCSF and later in the Max Planck Institute for Heart and Lung research in Germany, where he worked on non-coding RNAs during development and regeneration using new reverse genetics tools.  After delving into inconsistencies between different reverse genetic approaches, Zac’s interests shifted to more fundamental questions like why some mutations cause a phenotype while others don’t.  Zac joined the “Corn Lab” as Head of the Genome Engineering and Measurement Lab in August 2019.  Amongst his research interests are regulation of gene expression during physiology and disease, with a special focus on understanding penetrance and expressivity, two classical Genetics terms that are often collectively used to describe the black box that lies between genotype and phenotype.

Close

Susanne Kreutzer

Genomics Expert

Susanne received her PhD in Paleogenomics at ... Read Bio

Susanne received her PhD in Paleogenomics at the University of Mainz exploring the genetic makeup of ancient populations during the Neolithization process of Europe. After working at the Molecular Pathology group of the University Hospital in Zurich as a Research Associate, she joined the High Throughput Sequencing team of the Functional Genomics Center Zurich in 2017. Since 2019, she is working as a Genomics Expert together with Dr. Zacharias Kontarakis on Next Generation Sequencing workflows at GEML. Susanne joined the Corn Lab in September 2020 to support the team with high throughput sequencing applications.

Close

Shannon Mezger

Research Assistant
+41 44 633 36 15

Shannon received her Master’s... Read Bio

Close

Irene Sala

Technical Specialist
044 633 40 04

Irene received her MSc degree in Medical Biot... Read Bio

Irene received her MSc degree in Medical Biotechnology from the University of Modena and Reggio Emilia (Italy), where she worked on the characterization of the epidermal stemness regulatory network in Epidermolysis Bullosa. Later on, she joined Vector BioPharma AG as a research associate with a focus on immunology and genome editing in the development of adenovirus-based gene therapies. Irene joined the Corn Lab as a technical specialist in March 2024; her research interests focus on the therapeutic translation of genome editing technologies.

Close

Markus Schröder

Bioinformatics Scientist

Markus received his PhD in Computational Infe... Read Bio

Markus received his PhD in Computational Infection Biology from University College Dublin, Ireland, working with Prof. Geraldine Butler and Prof. Des Higgins on comparative genomics in human fungal pathogens, focusing on uncovering the population structure and characterizing transcriptional networks in Candida species. Markus joined the Corn lab staff as a Bioinformatics Scientist in May 2019 from Genentech, South San Francisco, where he worked on large scale cancer genomics and familial data sets. At ETHZ, he works on CRISPR- and NGS-related computational approaches and is part of the NCCR RNA & Disease.

Close

Rosie Viviani

Administrative Coordinator

Rosie joined ETH Zurich in December 2019 as... Read Bio

Rosie joined ETH Zurich in December 2019 as the Administrative Coordinator of the Corn lab. She has a solid commercial background and many years of experience in the commercial and finance field. Prior joining ETH, she worked over 16,5 years for F. Hoffmann-La Roche AG in Basel in various administrative and finance coordinator roles in the department of pRED, Pharma Business and Corporate.

Close

Iryna vykhlyantseva

Research Technician

Iryna Vykhlyantseva completed her master's de... Read Bio

Iryna Vykhlyantseva completed her master's degree in Biotechnology at Instituto Superior Técnico in late 2022. In July 2023, she joined the Corn Lab's GEML team as a research assistant. Her current work involves the application of genome editing tools and the analysis of editing outcomes in mammalian cells.

Close

Postdoctoral Fellows

Eric Aird

Postdoctoral Researcher
+41 44 633 40 04

Eric received his PhD in Biochemistry, Molecu... Read Bio

Eric received his PhD in Biochemistry, Molecular Biology, and Biophysics from the University of Minnesota in 2020 in the lab of Dr. Wendy Gordon developing improved genome editing technologies, including a Cas-DNA tethering platform. In November 2020, Eric joined the Corn Lab as a postdoc interested in studying synthetic lethalities and viabilities in DNA repair utilizing CRISPR.

Close

Marija Banović

Postdoctoral Researcher
+41 44 633 40 04

Marija received her Master’s degree in Medi... Read Bio

Marija received her Master’s degree in Medical Biotechnology from the University of Rijeka in 2015. She worked with Prof. Antonija Jurak Begonja on the role of Vps34 in proplatelet formation. She received her PhD in Genome Biology from ETH Zürich in 2024, working with Prof. Jacob Corn to identify mediators of erythroblast enucleation by CRISPR screening. She continued working in the Corn Lab as a postdoc in June 2024 and is currently studying the role of the exocyst complex in erythroblast enucleation.

Close

Grégoire Cullot

Postdoctoral Researcher
+41 44 633 40 04

Grégoire has received his Ph.D. in Cell Biol... Read Bio

Grégoire has received his Ph.D. in Cell Biology and Physiopathology from the University of Bordeaux (France) in December 2019 in the lab of Prof. Moreau-Gaudry. His work was interested in the gene therapy of congenital erythropoietic porphyria with a focus on the genotoxicity of CRISPR-Cas9 system. He continued with a one-year post-doctoral experience to apply the SHERLOCK detection system in the context of chronic myeloid leukemia. Grégoire joined the Corn lab as a post-doctoral researcher in January 2021. His research interests include gene editing and monogenic diseases, with a special focus on gene therapy of sickle cell disease.

Close

John Fielden

Postdoctoral Researcher
+41 44 633 40 04

John received his PhD in Oncology from the Un... Read Bio

John received his PhD in Oncology from the University of Oxford in 2020, working with Prof. Kristijan Ramadan on the molecular mechanisms of DNA-protein crosslink repair. John joined the Corn Lab as a postdoctoral researcher in October 2020, where he is using CRISPR-Cas9-based screening approaches to identify genetic interactions that can be exploited in cancer therapy.

Close

Danielle Gallagher

Postdoctoral Researcher

Danielle received her B. Sc. in Microbiology ... Read Bio

Danielle received her B. Sc. in Microbiology and Molecular Biology from Marshall University, where she did research on secondary metabolite production in plants. In 2021 she received her Ph.D. from Brandeis University where she worked with Dr. James Haber to characterize the mechanisms of gene editing via single strand template repair. Danielle joined the Corn lab in April 2021 as postdoctoral researcher with interests in further understanding the mechanisms of DNA damage and utilizing these insights to develop tools to edit the genome.

Close

Roman Iwasaki

Postdoctoral Researcher
+41 44 633 40 04

Roman received his B.Sc. from Universität Po... Read Bio

Roman received his B.Sc. from Universität Potsdam and his M.Sc. from the Humboldt-Universität Berlin where he worked on light-regulated, synthetic gene circuits in the group of Prof. Möglich. In 2020, Roman received his Ph.D. from the University of Boulder, where he had developed tools by combining CRISPR and aptamer components in the group of Prof. Batey. He is currently interested in finding new ways to understand DNA damage repair and developing new tools to easily modify DNA.

Close

Erman Karasu

Postdoctoral Researcher
+41 44 633 40 04

Erman received his Ph.D in molecular biology ... Read Bio

Erman received his Ph.D in molecular biology from Gerstner Sloan Kettering Graduate School in 2018, working with Dr. Scott Keeney focusing on the role two meiosis specific genes (cyclin B3 and Ankrd31)in mammalian meiosis. Erman joined the Corn Lab as a postdoc in May 2019, is currently using CRISPR-Cas9 mediated genome engineering to understand novel genetic pathways in response to DNA damage.

Close

David Morales

Postdoctoral Researcher
+41 44 633 40 04

David received his PhD in Biochemistry from t... Read Bio

David received his PhD in Biochemistry from the University of Cambridge in 2022 under the supervision of Prof. Steve Jackson. His work focused on identifying functional genetic interactions within the DNA damage response through CRISPR-Cas9 screens. David joined the Corn Lab as a postdoctoral researcher in October 2022. His research interests include DNA repair, CRISPR-Cas9 technologies, genetic screening, and therapeutic gene editing.

Close

Xiaojing Mu

Postdoctoral Researcher
+41 44 633 40 04

Xiaojing received her bachelor’s degree in ... Read Bio

Xiaojing received her bachelor’s degree in Molecular, Cellular and Developmental Biology from the University of Colorado at Boulder. In 2020, Xiaojing received her Ph.D. from Weill Cornell Graduate School of Medical Science, working with Dr. Scott Keeney on the mechanism to regulate meiotic DSB formation. Xiaojing joined the Corn Lab as a postdoctoral researcher in March 2021 with interests in studying DNA damage repair and implementation of therapeutic gene editing.  

Close

Matthias Muhar

Postdoctoral Researcher
+41 44 633 40 04

Matthias received his PhD in Molecular Biolog... Read Bio

Matthias received his PhD in Molecular Biology from the Institute of Molecular Pathology (IMP) in Vienna in 2018, working with Prof. Johannes Zuber on the development of genetic- and transcriptomics tools for the study of gene regulation in leukemia. In July 2019 Matthias joined the Corn Lab as Postdoc to study the genetic basis of selective protein degradation. His research interests include protein homeostasis and exploratory genetics, with a special focus on protein quality control.

Close

Carolyn Shembrey

Postdoctoral Researcher

Carolyn received her PhD in molecular oncolog... Read Bio

Carolyn received her PhD in molecular oncology from The University of Melbourne in 2021, working with Professor Frédéric Hollande on tumour and immunological heterogeneity in the context of metastatic colorectal cancer. She then completed a 3-year postdoc at the Peter MacCallum Cancer Centre (Melbourne, Australia) with Dr Mohamed Fareh, where she leveraged mismatch tolerance within the CRISPR-Cas13 system to selectively target point-mutated oncogenes with single-nucleotide precision. Carolyn joined the Corn lab as a postdoctoral researcher in June 2024. Her ongoing research interests include functional cancer (epi)genomics and harnessing next-generation genome editing tools for precision medicine.

Close

Graduate Students

Marwa Peters Al Bayati

PhD Student

Marwa Peters Al-Bayati received her MSc in Bi... Read Bio

Marwa Peters Al-Bayati received her MSc in Biology from ETH Zurich in February 2023. She worked in the lab of Prof. Dr. Yves Barral, with the focus on developing an inducible gene-knockout system to investigate the role of Slx5 in chromosome segregation in budding yeast. Marwa joined the Corn Lab as a PhD student in March 2023. Her work is on how chemical modification of semi-synthetic model protein affects protein degradation and finding the cellular machinery mediating this process. Her research interests include functional genomics, protein quality control, protein homeostasis as well as potential application in protein engineering for therapeutic purposes.

Close

Benedetta Bellinazzi

PhD Student

Benedetta Bellinazzi received her MSc degree ... Read Bio

Benedetta Bellinazzi received her MSc degree in Medical Biotechnology from San Raffaele University (Milan, Italy) in 2023. She worked on the use of base editors for the treatment of a rare neurodevelopmental genetic disease and on viral vector delivery to the brain. Benedetta joined the Corn Lab as a PhD student in January 2024, to acquire new knowledge on DNA damage repair mechanisms after genome editing. Her research interests include CRISPR evolution and its applications across various fields, ranging from basic research to molecular medicine.

Close

Martina Cernakova

PhD Student

Martina received her MSc in Biology from ETH ... Read Bio

Martina received her MSc in Biology from ETH Zurich in September 2022. She worked in the Corn lab, focusing on the role of the ubiquitin-proteasome system in an autosomal dominant form of cerebral palsy. Martina returned to the Corn lab as a PhD student in December 2022, investigating how chemical modification of the protein backbone affects protein stability. Her research interests include protein homeostasis and functional genomics, as well as the potential application of protein engineering in biotechnology.

Close

Fedor Gorbenko

PhD student
+41 44 633 40 04

Fedor Gorbenko received his Master’s degree... Read Bio

Fedor Gorbenko received his Master’s degree in Molecular biology from Moscow state University in 2018 in Russia. He worked in the laboratory of professor Pavel Georgiev and focused on Polycomb-mediated repression of gene expression in a Drosophila model. Fedor joined the Corn Lab as a PhD student in January 2020. He is working on discovering principles that regulate functioning of CRISPR-Cas systems with a special focus on Cas14-related systems. Fedor’s research interests include evolution of CRISPR-Cas systems and implementation of the technology in therapy.

Close

Jenna Rode

Master Student
044 633 40 04

Jenna Rode received her Bachelor’s degree i... Read Bio

Jenna Rode received her Bachelor’s degree in Molecular and Cell Biology from UC Berkeley in 2023, working in the lab of Professor Gary Karpen on the role of heterochromatin binding proteins in nuclear organization. Jenna joined the Corn Lab in September 2024. She is currently working on her Master’s thesis, focusing on discovering novel mechanisms of DNA-protein crosslink degradation.

Close

Moritz Schlapansky

PhD Student

Moritz Schlapansky received his Master’s de... Read Bio

Moritz Schlapansky received his Master’s degree in Molecular Biology from the University of Vienna in 2020. He worked in the laboratory of Professor Michael McManus at UCSF, focusing on the development of a novel genetic screening paradigm and targeted sequencing approaches in order to decipher cell state transitions. Moritz joined the Corn Lab as a PhD student in July 2020. He is using the CRISPR toolbox to delineate genetic interactions that could inspire new cancer therapeutics. Moritz’ research interests include functional genomics, therapeutic gene editing and cancer biology, with a special focus on technology development.

Close

Sebastian Siegner

PhD Student

Sebastian Siegner received his MSc in Biochem... Read Bio

Sebastian Siegner received his MSc in Biochemistry from ETH Zurich in December 2020 with his work on the therapeutic potential of CRISPR Base- and Prime-Editors for the genetic disease Fanconi Anemia.

Close

Lilly van de Venn

PhD student
+41 44 633 40 04

Lilly van de Venn received her Master’s deg... Read Bio

Lilly van de Venn received her Master’s degree in Biology from ETH Zurich in 2017, working with Prof. Dr. Gerald Schwank on genome editing, focusing on the development of DNA barcodes harnessing the CRISPR/Cas9 system. Lilly joined the Corn Lab as a PhD student in December 2018, investigating DNA double-strand break repair after cleavage with different Cas enzymes and off-target detection. Her research interests include DNA repair mechanisms, as well as the potential use of genome editing for therapeutic purposes.

Close

Charles Yeh

PhD student
+41 44 633 40 04

Charles Yeh received his Bachelor’s degree ... Read Bio

Charles Yeh received his Bachelor’s degree in Biochemistry and Molecular Biology from the University of Maryland, Baltimore County (UMBC) in 2014. He then joined the National Center for Advancing Translational Sciences at the National Institutes of Health (NCATS-NIH). As a member of the Therapeutics for Rare and Neglected Diseases (TRND) program, Charles developed and applied human stem cell-derived disease models to identify potential therapeutics for rare lysosomal storage disorders, including Farber and Wolman diseases. In 2018, he joined the IGI as a graduate student and is presently studying the mechanisms of DNA repair homology search in the context of gene editing.

Close

Lily Zheng

Master Student
044 633 40 04

Xinhe (Lily) Zheng received her Bachelor's de... Read Bio

Xinhe (Lily) Zheng received her Bachelor's degree in Molecular and Cell Biology from UC Berkeley in 2023. She is currently enrolled in the Molecular Mechanisms of Disease Master's program at ETH Zürich. Lily joined the Corn lab in July 2024. For her Master's thesis she is investigating the dynamics of homology search during homology-directed repair of DNA double-strand breaks. 

Close

Alumni

Staff

Name
IGI Position
New Position
Ron Baik picture

Ron Baik

Research associate

Research associate at Stanford

Matteo Bordi

Research associate

Clinical Data Manager at Merck

Julia Chu

Lab manager

Lab Manager, Paredes lab at UCSF

Gemma Curie

Lab Manager

Microbiologist at Idaho State Department of Agriculture

Prisca Iseli

Administrative Coordinator

Katelynn Kazane

Research Associate

Diego Lopez

Hong Ma

Research Associate I

Research Associate II in Richard Kramer Lab

Jonathan Vu

Research Associate

PhD student at UC Santa Barara

Stacia Wyman

Bioinformatics Scientist

Bioinformatics Scientist at the IGI

Elena Zelin

Research Scientist

Postdoctoral Fellows

Name
IGI Position
New Position

Mandy Boontanrart

Postdoctoral fellow

Mark DeWitt

Postdoc

Principal Scientist, Mammoth Biosciences

Benjamin Gowen

IGI-AZ Postdoctoral Fellow

Shaheen Kabir

Postdoctoral Fellow

Vickie Lin

IGI-AZ Postdoctoral Research Fellow

Chris Richardson

Postdoctoral Researcher

Jiyung Jenny Shin

Postdoctoral Researcher

Rachel Valenzuela

IGI-PFIZER Postdoctoral Fellow

Beeke Wienert

Postdoctoral researcher

Graduate Students

Name
IGI Position
New Position

Luca Bechter

Research Technician in the Genome Engineering and Measurement Lab (GEML) at ETH Zurich

Naomi Cantos

Masters student

Alexandra Clemens

Master Student

Leonard Jahnke

Master Student

PhD Student at Prof. Nicola Aceto's lab ETH Zurich IMHS

Emily Lingeman

NSF Graduate Fellow

Xin Luo

Master Student

Elia Mächler

Master Student

Weidmann Medical Technology AG , Researcher

Dominic Mailänder

Nicola Margelisch

Master Student

Jan Nelis

Master Student

Project Lead & Co-Founder Ariya Bio

Simone Ponta

Master Student

Pia Reichl

Masters student

Arik Shams

Graduate Student Researcher

Krzysztof Szablewski

Visiting Scholar

Sam Jonas Ulrich

Alan Wang

NSF Graduate Fellow

Undergraduates

Name
IGI Position
New Position

Saba Ahmed

Undergraduate Researcher

Paul Ayoub

Undergraduate Researcher

Leo Chen

Undergraduate Researcher

Graduate student. UCSF

Jennifer Eunhee Chung

Undergraduate Researcher

Research Associate in Kohn Lab at UCLA

Sharon Feng

Undergraduate Researcher

working at Stanford Medicine

Elizabeth Jeon

Undergraduate Researcher

Rachel Lew

Undergraduate Researcher

Research Associate in the Haldar Lab at the Gladstone Institutes

Weihan Liu

Undergraduate Researcher

Tracie Luong

Undergraduate Researcher

Nicki Naddaf

Undergraduate Researcher

Technician in the Lareau lab.

Jordan Ray

Research Associate

Shirley Jing Shao

Undergraduate Researcher

Google Accelerated Science

Ankita Singh

Undergraduate Researcher

Undergraduate Researcher at Danica Chen lab

Elena Slobodyanyuk

Undergraduate researcher

Graduate student, MIT

Julia Wang

Undergraduate Researcher

Annie Yau

Undergraduate Researcher

Contact Us

Questions and/or comments about Corn Lab and its activities may be addressed to:

JACOB.CORN@BIOL.ETHZ.CH

Share: