Welcome to Lena Kobel, who joins the lab as a Cell Line E...
Welcome to Lena Kobel, who joins the lab as a Cell Line Engineer. Lena has a long history in genome engineering, with previous experience in Martin Jinek's lab and at Caribou Biosciences. Lena will be working on precision cell models and screens to study the genetics of DNA damage and genome editing.
Welcome to Making the Cut, the IGI blog about next-gen genome editing and regulation. The main page is for official announcements, news, job postings, that kind of thing. This area is for personal...
Welcome to Making the Cut, the IGI blog about next-gen genome editing and regulation. The main page is for official announcements, news, job postings, that kind of thing. This area is for personal thoughts on what's happening in this incredible, crazy field. As well as where it should go in the future, where it's been in the past, and so on. Posts will be from myself (Jacob Corn, scientific director of the IGI), as well as from scientists, postdocs, and students in the lab. To encourage openness and discourage doublespeak, all posts are the uncensored views of the author. Comments are open as well, so please be civil. (I know, asking people on the internet to be civil is like carrying coals to Newcastle, but still...)
Welcome to Lena Kobel, who joins the lab as a Cell Line Engineer. Lena has a long history in genome engineering, with previous experience in Martin Jinek’s...
Today I’m going to talk about setting up a lab from a 10,000 foot view. I got thinking about this because my social media feed was recently filled with people announcing...
There’s a series of cyberpunk short stories and a book written in the 1980s by Bruce Sterling called The Schismatrix. It centers around two major offshoots...
It’s important to spend time outside the lab. And before you ask, that’s not why the blog has been dormant. I was teaching this last semester (a general biochemistry...
My lab recently published a paper, together with outstanding co-corresponding authors David Martin (CHORI) and Dana Carroll (University of Utah), in which...
Cas9 is usually pretty good at gene knockout. Except when it isn’t. Most people who have gotten their feet wet with gene editing have had an experience like that...
This post is all about establishing safety for CRISPR gene editing cures for human disease. Note that I did not say this post is about gene editing off-targets....
(This post has been sitting in my outbox for a bit thanks to some exciting developments in the lab, so excuse any “dated” references that are off...
This post is the first in a new, ongoing series: what are big challenges for CRISPR-based technologies, what progress have we made so far, and what might we look...
A few weeks ago, Jacob wrote a blog post about his recent experience with posting pre-prints to bioRxiv. His verdict? “…preprints are still an experiment rather...
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