CDN transporter collaboration with David Raulet published in Nature

Cells have many ways to figure out that something is wrong. One of these is cGAS, which makes a cyclic dinucleotide (CDN) to activate STING innate immune signaling. CDNs are made during bacterial infection and tumor progression, and CDN derivatives are in development to re-activate immune cells next to a tumor. But how do CDNs secreted into the environment get into a target cell? This was the question asked by David Raulet’s lab, who collaborated with us on a genome-wide CRISPRi screen to find the CDN transporter. We helped the Raulet lab identify the folate transporter (SLC19A1) as a CDN importer. The Raulet lab plus further collaboration with Joshua Woodward’s lab figured out the mechanism. Lingyin Li’s lab also identified the folate transporter in a parallel collaboration with Mike Bassik, reported in Molecular Cell. Congrats to former lab members Benjamin Gowen and Stacia Wyman, who were authors on the paper, now out in Nature!

SUBMIT A COMMENT

Your email address will not be published. Required fields are marked *

Filters

Please select

Latest News

February 26, 2025

Welcome to Rafaela!

Rafaela received her Master’s degree in Bioengineering from the University of Engineering of Porto in 2019, where she worked on the production and characterization...

February 24, 2025

Welcome to Boris!

Boris Korablev received his Bachelor’s degree in Molecular and Cell Biology from UC Berkeley in 2021. Before joining ETH, he worked at a gene-editing...

January 30, 2025

C-TERMINAL AMIDES FUNCTION AS SIGNALS FOR PROTEIN DEGRADATION- PUBLISHED IN NATURE

Proteins are essential building blocks of life, but they can become toxic to our cells if damaged, for example under oxidative stress. In turn, human cells ...

News Archive

Tweets