IGI receives CIRM CESCG CRP grant to study gene correction for SCD

The IGI has been awarded a CIRM grant to develop next-generation sequencing approaches to track gene correction in bone marrow stem cells for the treatment of sickle cell disease. The CIRM Center of Excellence in Stem Cell Genomics (CESCG) Collaborative Research Program (CRP) supports collaborative research projects by providing California scientists with access to cutting-edge genomics and bioinformatics technologies, and expertise and assistance in experimental design and data analysis. Working with CESCG, the IGI will determine how bone marrow stem cells respond to genetic engineering, characterize on- and off-target gene editing in these challenging cells, and work to move research on a gene editing cure for sickle cell disease closer to the clinic.

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