Pushing Cas9 off the genome, published in Molecular Cell
Cas9 is a great DNA cutting enzyme, but it’s also a little weird. Unlike other nucleases (such as restriction enzymes), S, pyogenes Cas9 sticks on ...
Increasing HDR by timed inhibition of CDC7, published in Nature Communications
When doing genome editing, fixing sequences by HDR is better than breaking them by making indels. If you really want to break something, you could even use HDR...
Welcome to Lena
Welcome to Lena Kobel, who joins the lab as a Cell Line Engineer. Lena has a long history in genome engineering, with previous experience in Martin Jinek’s lab...
- Every time I give a talk about #SickleCell #CRISPR, someone asks why fetal globin goes up after editing. New paper… https://t.co/jy5X5S7klg about 49 minutes ago ReplyRetweetFavorite
- RT @durocher1: Our human DNA damage network paper is finally out! See thread for updates on what changed since we posted our BioRxiv prepri… Jul 09 ReplyRetweetFavorite
- Stop whatever you're doing and read this. Actually, better get a tissue, first. Strength, love, perseverance. Amazi… https://t.co/jlMdKQ7sQd Jul 08 ReplyRetweetFavorite
- RT @davidrliu: Today we report in @nature, in collaboration with the labs of Joseph Mougous and @VamsiMootha, the development of a new clas… Jul 08 ReplyRetweetFavorite