Jacob Corn awarded the prestigious NIH “New Innovator” Grant

IGI Scientific Director of Biomedicine Jacob Corn has received the NIH Director’s New Innovator Award that provides $1.5 million over five years to pursue high-risk, high-reward work that could have implications for human health. The National Institutes of Health’s (NIH) High-Risk, High-Reward Research program, part of the NIH Common Fund, funded 86 awards to exceptionally creative scientists proposing to use highly innovative approaches to tackle major challenges in biomedical research.

Corn lab will use CRISPR-Cas9 gene editing to explore how cells recycle damaged organs, such as mitochondria. Dysfunction in organelle autophagy has been implicated in diverse diseases, including neurodegeneration, lysosomal storage disorders and cancer.  Corn lab will use next- generation CRISPR-Cas9 genome editing and regulation technologies, combined with cellular biochemistry and imaging to discover the pathways that signal for the remodeling and lysosomal degradation of multiple organelles.  Our work will reveal the mechanisms by which cells maintain organelle homeostasis and respond to organelle damage or stress, which could suggest new strategies to treat diseases associated with improper organelle autophagy.

SUBMIT A COMMENT

Your email address will not be published. Required fields are marked *

Filters

Latest News

January 16, 2019

We’re hiring!

Are you interested in working on genome editing, DNA repair, and organelle quality control in a dynamic lab environment? We are seeking a technician/lab manager...

December 5, 2018

Welcome to our new Ph.D. students

We have two new Ph.D. students at ETH Zurich: Marija Banovic and Lilly van de Venn. Marija is interested in the biology of hematopoietic stem/progenitor cells...

December 1, 2018

Happy Thanksgiving!

We had an slightly belated American Thanksgiving in Zürich, complete with turkey, stuffing, mashed potatoes, and gravy. After eating more than our fill,...

News Archive

Tweets