Lab News

CRISPR-SCREENS IN ORGANELLE AUTOPHAGY- REVIEW PUBLISHED IN TRENDS IN CELL BIOLOGY

Are you interested in autophagy of really big things in the cells, such as organelles?  Are you wondering how cutting-edge genetic tools can accelerate your...

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Are you interested in autophagy of really big things in the cells, such as organelles?  Are you wondering how cutting-edge genetic tools can accelerate your autophagy research? Jin Rui Liang (Amos), a former postdoc, now running his own group at the University of Dundee, wrote a comprehensive review on CRISPR’s impact on autophagy research. Amos outlines the major considerations for CRISPR-based genetic manipulations in autophagy, with a focus on genome-wide screening, as well as various reporter systems for high-throughput autophagy quantification. The article thoroughly summarizes all the relevant info on recently performed autophagy-related screens and their discoveries. Have a CRISPR-view on autophagy, now out in Trends in Cell Biology!

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Welcome to David

David received his PhD in Biochemistry from the University of Cambridge in 2022 under the supervision of Prof. Steve Jackson. His work focused on identifying...

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David received his PhD in Biochemistry from the University of Cambridge in 2022 under the supervision of Prof. Steve Jackson. His work focused on identifying functional genetic interactions within the DNA damage response through CRISPR-Cas9 screens. David joined the Corn Lab as a postdoctoral researcher in October 2022. 

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Welcome to Jan

Jan received his Master´s degree in Immunology from Charles University in 2022, working with Dr. Petr Kašpárek on the role of TNFR1 signalling in the Netherton...

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Jan received his Master´s degree in Immunology from Charles University in 2022, working with Dr. Petr Kašpárek on the role of TNFR1 signalling in the Netherton syndrome. Jan joined the Corn Lab as a Research Assistant in September 2022 and his research interests include regulation of gene expression and synthetic biology, with a special focus on utilizing the CRISPRa/i technologies in therapeutic applications.

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Welcome to Ana

Ana received her PhD in Cancer Biology at the University of Zurich, Switzerland. She carried out her pre-and postdoctoral research studies at the Balgrist...

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Ana received her PhD in Cancer Biology at the University of Zurich, Switzerland. She carried out her pre-and postdoctoral research studies at the Balgrist University Hospital in Zurich focusing on understanding the molecular mechanisms of bone cancer progression and metastasis, identifying the key regulatory components as well as finding novel innovative therapeutic approaches. Ana joined the Corn lab as a Program Manager in September 2022.

 

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Congrats to Mandy on the BRIDGE grant!

Mandy received the BRIDGE Proof-of-Concept grant for her research on hemoglobin diseases. The BRIDGE programme is jointly offered by the Swiss National ...

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Mandy received the BRIDGE Proof-of-Concept grant for her research on hemoglobin diseases. The BRIDGE programme is jointly offered by the Swiss National Science Foundation (SNSF) and Innosuisse.

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Welcome to Martina

Martina received her BSc degree in Biochemistry at the Imperial College London, graduating in July 2020. She joined the Corn Lab in February 2022 and her Master...

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Martina received her BSc degree in Biochemistry at the Imperial College London, graduating in July 2020. She joined the Corn Lab in February 2022 and her Master thesis involves using genome engineering and interaction proteomics to study the role of the ubiquitin-proteasome system in neurodevelopmental disorders. Her research interests include protein quality control, functional genomics, tissue repair and neurobiology.

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Welcome to Simone

Simone received his Bachelor’s degree in Biotechnology in 2020, from the Università del Piemonte Orientale, Novara, Italy. He joined the Corn Lab in July ...

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Simone received his Bachelor’s degree in Biotechnology in 2020, from the Università del Piemonte Orientale, Novara, Italy. He joined the Corn Lab in July 2021 and his research interest involves understanding overall cell biology and how disbalances in fundamental molecular processes cause diseases. He seeks to engage in translational medicine, to contribute developing novel functional therapeutic treatments.

 

 

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Welcome to Sam

Sam received his Bachelor’s degree in Health Science and Technology from ETH Zürich in 2021. He joined the Corn Lab as a Master student in May 2021 working on ...

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Sam received his Bachelor’s degree in Health Science and Technology from ETH Zürich in 2021. He joined the Corn Lab as a Master student in May 2021 working on a CRISPR-based approach to validate and functionally characterise regulators and receptors involved in ER-phagy. His research interests include genome engineering, functional genomics, cancer and neuropathy.

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Welcome to Jan

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Congratulations to Amos Liang for establishing his independent research group

One of our postdocs, Amos Liang, will be setting up his own research group at the Medical Research Council-Protein Phosphorylation and Ubiquitylation Unit...

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One of our postdocs, Amos Liang, will be setting up his own research group at the Medical Research Council-Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU) at the University of Dundee in June 2022. His group will expand on his previous work to understand the mechanisms and physiological roles of endoplasmic reticulum turnover via autophagy using CRISPR-based gene editing and genome-wide screening technology, fluorescence-activated cell sorting (FACS), mass spectrometry, fluorescence microscopy, and biochemical studies. We wish him all the best and we are excited for what the future holds for his new lab!

For more information on the research focus of Amos’ group, please visit here.

 

 

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